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Featured Review: Imaging with PET during chemotherapy to predict outcome in adults with Hodgkin lymphoma

Tue, 09/17/2019 - 08:10

Hodgkin lymphoma (HL) is one of the most common haematological malignancies in young adults and, with cure rates of 90%, has become curable for the majority of individuals. Positron emission tomography (PET) is an imaging tool used to monitor a tumour’s metabolic activity, stage and progression. Interim PET during chemotherapy has been posited as a prognostic factor in individuals with HL to distinguish between those with a poor prognosis and those with a better prognosis. This distinction is important to inform decision-making on the clinical pathway of individuals with HL.

In this interview with the lead author of this Review we asked Research Associate, Angela Aldin from Cochrane Haematological Malignancies to tell us more about it.

What is (interim) PET and what does the PET scan result indicate?
A positron emission tomography (PET) is an imaging tool that is used for the diagnosis and/or monitoring of a disease. In individuals with Hodgkin lymphoma (HL), a PET scan at diagnosis helps to identify the stage of the disease and aids the treating physician in deciding upon the treatment pathway of the individual. An interim PET scan, however, is conducted during therapy, for instance after the second cycle of chemotherapy, to see whether the individual is responding to the allocated treatment. The Deauville five-point scale is the most commonly used scale for the interpretation of the scans and for assessing the extent of the disease. For example, individuals with a score of four or five are said to have a positive PET scan result, as the PET scan shows a higher uptake and metabolic activity of the cancer cells, and noticeable evidence of disease. Individuals with a score between one and three have a negative PET scan with a lower uptake of the cancer cells.

What was the objective of this review?
The objective of this review was to determine whether in previously untreated adults with HL (all stages) receiving first-line therapy, interim PET scan results (i.e. a positive or a negative result) can distinguish between those with a poor prognosis and those with a better prognosis, and thereby predict survival in each group.

How many studies were included? What was included and what was excluded?
We included twenty-three studies in total, in this review. In all studies, interim PET was conducted during first-line therapy and after two, three, and/or four cycles of chemotherapy in adults with HL (all stages). We included both retrospective and prospective studies that provided evidence on our prognostic factor of interest (interim PET-scan results) and outcomes of interest (overall survival, progression-free survival and PET-associated adverse events). It was important to include studies in which the treatment regimen of the participants was not adapted according to the interim PET scan results. In other words, irrespective of the interim PET scan result (interim PET-positive or interim PET-negative), participants should continue with the same treatment regimen as specified at the beginning of the study. The reason being that the occurrence of the predicted outcome in each group shall be attributable to the prognostic factor of interest (the interim PET scan result) rather than the modified treatments. Hence, we excluded studies that in their design allowed adaptation of the initially allocated treatment regimen of participants based on their interim PET scan result. In other words, modification of treatment based on the PET results would mask the true impact of the interim-PET as a prognostic factor. Once the significance of the interim-PET results is proven (as this was the aim of the review), then a different type of clinical study would be necessary before recommendations for treatment alterations based on PET results is offered to clinicians.

How certain is the evidence?
We pooled unadjusted effect estimates for overall survival (only nine studies offered relevant data) and progression-free survival (fourteen studies). Our concerns regarding the certainty of the evidence mainly lie with the methodology of the primary studies, particularly the reporting and presentation of the study results. Hence, we could not include all studies in meta-analysis and have very low to moderate certainty in the evidence.

For overall survival, we have moderate-certainty evidence that individuals with HL who have a negative interim PET scan result have better survival compared to those with a positive interim PET scan result.

For progression-free survival, we have very low certainty-evidence that individuals who have a negative interim PET scan result may have longer cancer free periods compared to those with a positive interim PET scan result. For this outcome, we also found some inconsistency as to how the outcome was defined as it is a composite outcome containing different endpoints.

We are not able to comment on PET-associated adverse events as no study measured nor reported these.

Are there different types of prognosis reviews?
This review is a systematic review of prognostic factor studies (type 2 below). However, there are four different types of studies on prognosis:

  1. Studies on overall prognosis (i.e. the likely outcome or course of a certain health condition)
  2. Prognostic factor studies (i.e. factors that are associated with a certain health outcome)
  3. Prognostic model studies (i.e. a combination/set of prognostic factors that together predict a certain health outcome)
  4. Stratified medicine research (i.e. using prognostic factors and models to guide the individual treatment path).

Reviews of studies on prognosis fit with the move towards new innovative review types, as the methodology behind the assessment of these studies as well as the pooling and summary of individual study results from studies on prognosis is still new and under development. An accurate and correct prognosis of health-related outcomes lies at the heart of each individual. Therefore, it is important to define and continuously refine the methodology of such reviews in order to be able to provide a good and thorough overview of the evidence on a specific research question related to prognosis.

Why was this topic considered to be high priority and therefore eligible for Cochrane’s Fast- Track initiative, and what was your experience of working with Cochrane Fast-Track?
This project was funded by the German Federal Ministry of Education and Research (01KG1709) as it answers a clinically relevant question that interim PET successfully distinguishes between individuals with a poor prognosis (interim PET-positive) and individuals with a good prognosis (interim PET-negative). This evidence can aid clinical decision-making on the treatment pathway of affected individuals with HL. The treatment pathway of an individual may be adapted based on their interim PET scan result in order to receive the treatment with the greatest efficacy and least toxicity possible. Furthermore, HL is a disease that is most common in young adults.

The evidence that this review provides may also be used in national and international clinical guidelines regarding the treatment pathways of individuals with HL. Further reasons as to why it was considered to be a high priority review and was therefore eligible for the Fast Track is because it is the first Cochrane prognostic factor review with meta-analysis in the Cochrane Library. It was developed through close collaboration with the Cochrane Prognosis Methods Group, as well as the GRADE Prognosis Working Group. The conduct of systematic reviews of prognosis studies is increasingly growing and with our review we try to contribute to the methodological developments and provide a guide for future authors of such reviews. Therefore, the author team applied to the Fast Track team due to the above mentioned reasons and the review met the eligibility criteria and was considered to be an important review for Cochrane. We had a very positive experience with the Cochrane Fast-Track team. We were guided and supported through each step of the editorial and publishing phase, and were continuously updated by the team regarding the status of our review. We received very thorough and detailed feedback from internal and external peer- reviewers who greatly helped in improving this review.

Photo credit: Uniklinik Köln

Wednesday, September 11, 2019

Cochrane International Mobility – launch of pilot programme

Mon, 09/16/2019 - 13:55

Getting involved in Cochrane’s work means becoming part of a global community. Connect with Cochrane Groups across the world through the Cochrane International Mobility programme!

The Cochrane International Mobility programme builds on previous successful student exchanges involving Cochrane Centres around the world. A broader initiative involving twelve Cochrane Groups has now been launched as a pilot by Cochrane People Services Department.

Successful applicants will complete a placement in a host Group, learning more about the production, use and knowledge translation of Cochrane reviews.

Gain skills and experience

Arrangements are flexible and placements can vary in length, depending on the project plan. Placements are typically self-funded. Participants completing postgraduate study have benefitted from university funding, and some Groups can offer work space or accommodation. Training and mentoring support is offered in different areas, specific to Groups' expertise.

Chris Champion, Head of People Services, Cochrane Central Executive, said “This is an exciting opportunity to pilot ways to support community learning and development that makes the most of Cochrane’s network of members across the globe. The programme offers opportunities for people involved in Cochrane - particularly at an early stage in their careers - to benefit from experiences in other contexts. It also encourages networking and skills development across Groups both for those who are visiting and for those supporting them.”

Learn from each other

Cochrane International Mobility offers opportunities for learning and training not only for participants but also for host staff. Cochrane Croatia welcomed a student intern this summer as part of the fledgling programme.

“I’m very grateful to Cochrane Croatia for hosting me and for this wonderful experience, and I’m sure I’ll be using all the skills I learned as I continue on in my academic career,” said Sarah Tanveer, Cochrane International Mobility participant, summer 2019.

Tina Poklepović Peričić, Co-director, Cochrane Croatia added, “This was an encouraging experience for us all, and spending time with Sarah, exchanging experiences, teaching and working with her was a true refreshment to our Centre.”

Apply now

Find out more about the programme on Cochrane Training or search for opportunities on Cochrane TaskExchange.

Monday, September 16, 2019

Evidence Synthesis - What is it and why do we need it?

Fri, 09/13/2019 - 17:33

We encounter Evidence Syntheses on an almost day-to-day basis, but do we know what it is and why we need it?

Cochrane Ireland and Evidence Synthesis Ireland aims to build knowledge, awareness, and capacity in the methods used to gather and build evidence (known as evidence synthesis) and using it effectively to inform health and healthcare decisions in Ireland. Policy makers, healthcare institutions, clinicians, researchers and the public will stand to benefit.

Evidence synthesis, also sometimes called “systematic reviews”, is a way of combining information from multiple studies that have investigated the same thing, to come to an overall understanding of what they found. This helps determine how effective a certain treatment or drug is, or how people have experienced a particular health condition or treatment.

Friday, September 13, 2019

Podcast: Effects of starting antiretroviral therapy within one week of diagnosis on people living with HIV

Fri, 09/13/2019 - 10:22

Among the dozens of Cochrane Reviews of various treatments for people with HIV or AIDS, are some that look more at how the treatments should be used, rather than the treatments themselves. One of these examines the timing of the start of treatment, and it was published in June 2019. Lead author, Alberto Mateo from the Liverpool School of Tropical Medicine in the UK, tells us about the evidence base and the findings for this important question.

"When people are diagnosed with HIV, they normally have to attend several clinic visits before they are offered treatment. This is to make sure that they are ready and that it is safe to start the medication. However, attending many clinic visits may be a barrier for people, particularly in low- and middle-income countries, which means that many of them stop being engaged with health services and never actually start the treatment. This makes them at risk of dying sooner than people on the therapy.

One proposed solution is to offer the antiretroviral therapy, or ART, on the same day that the person is diagnosed, or within a few days, what is known as “rapid ART”. We wanted to investigate if doing this could reduce mortality and improve other outcomes, and our review has found that rapid ART probably does increase the number of people initiating the therapy and the number of people with no detectable level of virus in the blood 12 months after diagnosis. We also found that rapid ART may increase the number of people in contact with healthcare services.

However, the evidence currently available does not allow us to say whether rapid ART reduces mortality. Some authors have previously suggested that giving ART so quickly after diagnosis could increase the number of drug adverse effects, and we did not have enough data to analyse this either.

It is important to note that in all the studies included in our review, rapid ART was delivered alongside several other interventions which needed to be in place to make rapid ART possible. These interventions allowed healthcare services to diagnose and assess the physical and psychological health of people with HIV to see if they were ready to start ART.

Looking forward, we hope that future studies will help to consolidate these promising findings, as well as determining which interventions help best to deliver rapid ART.”

Friday, September 13, 2019

Colloquium Scientific Program at a glance

Wed, 09/11/2019 - 14:47

Cochrane Chile is thrilled to present highlights of this year’s Scientific Program! Cochrane’s annual flagship event brings together hundreds of clinicians, health professionals, policy makers, researchers, patients, consumers and others to discuss and learn about the wide usage of Cochrane evidence in health decision-making at all levels. This year’s Colloquium will take place 22-25 October, with the theme “Embracing diversity”. Pre-Colloquium activities start October 20.

The Full Schedule of the Scientific Program is now published!

Three Plenary Sessions will discuss the importance of evidence for Health Equity, its use by Diverse Stakeholders, and the importance of embracing Methodological Diversity.

The Cochrane Lecture will be given by Andy Oxman, and will explore the diversity of options for the future of the Cochrane Collaboration.

Nine Special Sessions, two presented in Spanish, will highlight innovative and interesting topics, varying from advances in the new Cochrane Handbook to multiple sessions on aspects of linguistic diversity in Cochrane; from engaging healthcare consumers in evidence, to technological innovation integrated with the evidence ecosystem.  

Concurrent sessions will offer 63 workshops ranging across 18 topic categories. For the first time, 8 workshops will be presented in Spanish!

Fifty one oral presentation sessions will include 241 presentations and three poster sessions will comprise 242 posters, covering topics from 17 different categories. Posters and orals are presented by delegates from all over the world.

We are so excited to welcome you to Santiago! There is still time to register before the Standard Registration deadline.

See you soon!

Wednesday, September 11, 2019

Cochrane Neck and Back abstracts receive high praise in recent study

Tue, 09/10/2019 - 20:21

A recent study comparing low back pain systematic reviews abstracts to their full text was published in the Journal of Orthopaedic & Sports Physical Therapy. Looking at 66 systematic reviews reserchers found that 80% of abstracts presented spin and inconsistencies when compared to their full text. 9 of the systematic reviews investigated were Cochrane Reviews and it was found that  "Cochrane review abstracts had substantial to almost perfect agreement with the full text."

Lower back pain reviews are overseen by Cochrane Back and Neck (CBN). CBN coordinates the publication of literature reviews of diagnosis, primary and secondary prevention and treatment of neck and back pain and other spinal disorders, excluding inflammatory diseases and fractures. CBN is hosted by the Institute for Work & Health (IWH) in Toronto, Canada. IWH is an independent, not-for-profit organization. Its mission is to conduct and share research that protects and improves the health of working people and is valued by policy-makers, workers, workplaces, clinicians, and health & safety professionals.

 

 

Tuesday, September 10, 2019

Czech Republic to host Global Evidence Summit 2021

Tue, 09/10/2019 - 17:21

 

Cochrane, JBI, Campbell Collaboration and Guidelines International Network are excited to announce the host of the Global Evidence Summit (GES) 2021 is the Czech National Centre for Evidence-Based Healthcare and Knowledge Translation (CEBHCKT).

The Cochrane geographic Centre is a leading national umbrella institution for evidence-based healthcare and guideline development, inclusive of a JBI Centre of Excellence, a Guidelines International Network member and the Masaryk University GRADE Centre.

The Centre was selected after a competitive application process that saw organizations from around the world contest to host the Global Evidence Summit in 2021. Professor Andrea Pokorná, Deputy Director of the Czech National Centre for Evidence-Based Healthcare and Knowledge Translation, is delighted that the Centre will host the Summit:

“Winning the bid to host is a great achievement that will influence the provision of healthcare in Central Europe, particularly in the Czech Republic. I am very proud that Masaryk University and its Centre for Evidence-based Healthcare and Knowledge Translation will be host to the Summit in 2021.”

The Global Evidence Summit 2021 will be held in October at O2 Universum, the brand new Multifunctional Cultural and Congress Centre in beautiful historic Prague and is easily accessible from every city quarter.  Prague is home to one of the most complete ensembles of Renaissance, Gothic and Baroque architecture in Europe.

Director of Cochrane Czech Republic and the Czech National Centre for Evidence-Based Healthcare and Knowledge Translation, Dr Miloslav Klugar, said that by partnering to deliver the Global Evidence Summit the four organizing partners send a message that co-operation and knowledge sharing must be embraced to improve health and the quality of life for people globally: “The Global Evidence Summit 2021 is an exciting opportunity for us here in the Czech Republic, Central Europe and everyone around the world to create synergies and to benefit from knowledge sharing in the global evidence community.”

Deputy Director, Dr Jitka Klugarová, added, “We are very proud that the Global Evidence Summit 2021 will take place in the Czech Republic. It is an amazing opportunity for global stakeholders in healthcare, research, social justice and education to participate in a global discussion about evidence-based practice.”

The GES is a quadrennial event that brings together some of the world’s leading organizations in evidence-based practice in a shared mission to provide a platform to discuss critical issues across different sectors, including health, education, social justice, the environment and climate change. The GES is intended as a multi-disciplinary and cross-cultural event to exchange ideas about how we best produce, summarize and disseminate evidence to inform policy and practice, and using that evidence to improve people’s lives across the world.

Together with the host, the Czech National Centre for Evidence-Based Healthcare and Knowledge Translation, Cochrane, JBI, Campbell Collaboration, and Guidelines International Network intend the second Global Evidence Summit to build on the successes of the 2017 Summit in Cape Town to advance the use of reliable research evidence in addressing some of the world’s most serious health and social challenges.

 

Wednesday, September 11, 2019

Featured Review: Treating school children with drugs to kill soil - transmitted worms

Tue, 09/10/2019 - 09:08

In 2015 Cochrane published a review on this topic, which has now been updated to include six new trials, additional data from included trials, and addresses comments and criticisms.

Global Advocacy organisations claim routine deworming of all school children at regular intervals with deworming drugs in areas where helminth infection is common has substantive health and societal effects beyond the removal of worms.

This interview with David Taylor Robinson, Professor of Public Health and Policy, Honorary Consultant in Child Public Health at The University of Liverpool, tells us a little more about this review.

What is deworming and why is it important?
Soil-transmitted worms, including roundworms, hookworms, and whipworms, are common in tropical and subtropical areas, and particularly affect children living in poverty where there is inadequate sanitation. The World Health Organization (WHO) currently recommends that school children in many areas are regularly treated with drugs which kill these worms. Some advocates claim such programmes improve child growth, haemoglobin, cognition, school attendance, school performance, physical fitness, and survival.

What is the history of this Cochrane Review?
A summary is given here in this Cochrane editorial which gives some of the background to this debated area.  Advocates believe strongly in population wide treatment programmes but the Cochrane review finds quite substantial evidence of no benefit in terms of haemoglobin, cognition, school performance, and mortality.

How widely is periodic deworming for children living in endemic areas advocated?
Periodic deworming for children living in endemic areas has been advocated by organizations as influential as the World Health Organization, the World Bank, and the Bill & Melinda Gates Foundation, and it has been considered to be a fundamental solution to the problems associated with endemic soil‐transmitted helminth infections.

What did this update aim to do?
To summarize the effects of public health programmes to regularly treat all children with deworming drugs on child growth, haemoglobin, cognition, school attendance, school performance, physical fitness, and mortality.

The evidence of no effect presented in the 2015 Cochrane Review was firm. Is this still the case with the 2019 review?
Yes, the overall conclusions are the same. We have included data from six additional trials in the update and have addressed comments and criticisms following the 2015 version – as with the 2015 version we see substantial evidence of no benefit for haemoglobin, cognition, school performance, and mortality. For weight studies conducted in two settings over 20 years ago showed large effects on weight, but this hasn’t been shown in more recent larger studies. 



Tell us more about how this update was conducted?
Cochrane researchers examined the effects of deworming children in areas where intestinal worm infection is common. After searching for relevant trials up to 19 September 2018, we included 50 trials with a total of 84,336 participants, and an additional trial of one million children.

It includes randomised controlled trials (RCTs) and quasi-RCTs that compared deworming drugs for soil-transmitted helminths (STH) with placebo or no treatment in children aged 16 years or less, reporting on weight, height, haemoglobin, and formal tests of cognition. We also sought data on other measures of growth, school attendance, school performance, physical fitness, and mortality.

What does the 2019 Cochrane Review tell us?
In populations of children living in endemic areas, the effect of the first, single dose of deworming drugs on weight is unclear. There was little or no effect in most studies, except for a large effect detected from one study area in Kenya, reported in two trials carried out over 30 years ago in a school where children were heavily infected with worms. This causes uncertainty which means we do not know if a first dose or single dose of deworming impacts on weight. For height, most studies showed little or no effect, with the exception of the site in Kenya. A single dose of deworming medicine probably has no effect on haemoglobin and cognition. There is insufficient data to know if there is an effect on school attendance, school performance, or physical fitness or mortality.

In studies where children were regularly treated with deworming medicine there was little or no effect on weight in all but two trials, irrespective of whether children were heavily infected with worms or not. The two trials with large average weight gains included the Kenya study carried out over 30 years ago, and one study from India carried out over 20 years ago in a low worm burden area where later studies in the same area did not show an effect. In trials from 2000 onwards, which are more relevant given the global reduction in worm burden, there is little or no effect. This causes uncertainty and means we do not know if regularly treating children with deworming medicine improves their weight. Regularly deworming children probably has no effect on height, haemoglobin, cognition, and mortality. We do not know if there is an impact on school attendance, since the evidence is inconsistent and at high risk of bias. There is insufficient data to know if there is an effect on physical fitness.

What criticism or comments does it address?
We addressed some detailed comments from deworming advocates which were helpful, and we included some new studies as a result of this. Also, previous criticisms concerned splitting the analysis between people known to be infected and community studies where whole populations are treated. In this update we conducted a fresh analysis considering all the data together, stratified on the basis of worm burden. We also repeated the analysis for different worm types.

What message does this review have for policy makers and those delivering public health programmes?
For public health programmes to regularly treat all children in endemic areas with deworming drugs, there is quite substantial evidence of no benefit in terms of haemoglobin, cognition, school performance, and mortality. For weight, contemporary studies do not show an effect, but unusually large effects were seen in studies over 20 years ago. We would caution against selecting only the evidence from these older studies as a rationale for contemporary mass treatment programmes.

What do you hope might happen as a result of this evidence update?
We suggest that the current evidence does not support large public health programmes of deworming in low and middle- income countries. Countries implementing such programmes should consider the findings of our updated review and make their own minds up. People developing global guidelines should be clear on what basis deworming programmes are being promoted.

Wednesday, September 11, 2019

Cochrane seeks Publishing Technology Manager - London

Mon, 09/09/2019 - 12:02

Specifications: Full time, permanent 
Salary: Competitive
Location: London
Application Closing Date: 2nd October 2019 (12 midnight GMT)

This role is an exciting opportunity to use your experience as a Publishing Technology Manager to make a difference in the field of health care research. 

The Publishing Technology Manager will join Cochrane’s product team to oversee the management and development of the external publishing technology systems and vendors, including the editorial management system and production system.

The Publishing Technology Manager will work with the technology vendors, the Product Lead, Head of Review Production and Senior Editor (Publishing Operations) to ensure that Cochrane content is processed on time and to the desired specifications, and that any necessary development work or dependencies for new content types or workflows are captured and resolved.

We are looking for a self-motivated and highly organised individual who is able to work effectively and collaboratively with a diverse range of contacts across the world.  The successful candidate will also have:

  • Educated to degree-level (or equivalent experience).
  • Experience of production systems, typesetters and paginators within scientific publishing.
  • Experience with web-based submission systems.
  • Fluent in English (written and spoken).
  • Excellent written and verbal communication skills.
  • Proven ability to establish and maintain positive relationships with people and teams from a range of
  • functional, professional, linguistic and cultural backgrounds.
  • Demonstrable experience of holding people to account.
  • Exceptional organisation skills and the ability to manage multiple projects at once.
  • Theoretical and practical experience of change management.
  • An understanding of how technology is affecting innovation within STM journal production and operations.

Cochrane is a global, independent network of health practitioners, researchers, patient advocates and others, responding to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesizing research findings to produce the best available evidence on what can work, what might harm and where more research is needed. Our work is recognised as the international gold standard for high quality, trusted information.

If you would like to apply for this position, please send a CV along with a supporting statement to recruitment@cochrane.org with “Publishing Technology Manager” in the subject line.  The supporting statement should indicate why you are applying for the post, and how far you meet the requirements for the post outlined in the job description using specific examples.  List your experience, achievements, knowledge, personal qualities, and skills which you feel are relevant to the post.

  • For further information, please download the full job description from here.
  • Deadline for applications: 2nd October 2019 (12 midnight GMT)
  • Interviews to be held on: (TBC)
Monday, September 9, 2019

Cochrane seeks Senior Editorial Officer

Wed, 09/04/2019 - 09:26

Specifications: Part time (0.6) permanent 
Salary: Competitive
Location: London
Application Closing Date: 30th September 2019 (12 midnight GMT)

This role is an exciting opportunity to use your experience as a Senior Editorial Officer to make a difference in the field of health care research. 

The Senior Editorial Officer will support the Editor in Chief of Cochrane in achieving the strategic aims and delivering the objectives of the Cochrane Editorial and Methods Department (EMD). 

The Senior Editorial Officer will lead and oversee strategic projects, including:

  • Working with the Editorial and Communications Officer on strategic projects or programmes of works relevant to the strategic vision for Cochrane’s content and review production.
  • Supporting effective and timely communications between the Editorial and Methods Department and other departments of the Cochrane Executive Team.
  • Lead the development of editorial projects and plans for making Cochrane reviews more accessible (in liaison with the KT Department and IRD).
  • Working with the Peoples Services Department on projects aiming to improve authors’ experiences. This includes the delivery of Editorial and Author Charters describing agreed expectations between Networks, authors and CRGs to assure the equity and consistently high quality of the review process.
  • Implementing the agreed quality-assurance process for high-profile reviews.
  • Supporting the Head of Review Production on operational projects relevant to the Cochrane Review Group (CRG) Networks including:
    • The implementation of the new Editorial Management System;
    • The development of Centralised Editorial Services;
    • The introduction of a new journal submission process; and
    • Editorial policy and process implementation.

We are looking for a self-motivated and highly organised individual who is able to work effectively and collaboratively with a diverse range of contacts across the world.  The successful candidate will also have:

  • An understanding of the importance of systematic reviews to clinical decision-making.
  • An ability to work alongside varied teams in different cultural and linguistic settings.
  • Strong organization and prioritization skills
  • Attention to detail
  • Excellent written and verbal communication skills
  • Impressive interpersonal skills both in person and by telephone and Skype.
  • An ability to accomplish projects with little supervision.
  • Intermediate-level IT skills, including proficiency in Word, Excel and PowerPoint.
  • An ability to develop and maintain good working relationships with key stakeholders.
  • Knowledge of and commitment to Cochrane’s mission and values and good understanding of Cochrane’s Strategy 2020 goals and targets.

Cochrane is a global, independent network of health practitioners, researchers, patient advocates and others, responding to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesizing research findings to produce the best available evidence on what can work, what might harm and where more research is needed. Our work is recognised as the international gold standard for high quality, trusted information.

If you would like to apply for this position, please send a CV along with a supporting statement to recruitment@cochrane.org with “Senior Editorial Officer” in the subject line.  The supporting statement should indicate why you are applying for the post, and how far you meet the requirements for the post outlined in the job description using specific examples.  List your experience, achievements, knowledge, personal qualities, and skills which you feel are relevant to the post.

  • For further information, please download the full job description from here.
  • Deadline for applications: 30th September 2019 (12 midnight GMT)
  • Interviews to be held on: (TBC)


Wednesday, September 4, 2019 Category: Jobs

Polycystic Ovary Syndrome Awareness Month

Tue, 09/03/2019 - 17:36

September is  Polycystic Ovary Syndrome Awareness Month and is an excellent time to focus on the latest Cochrane evidence.

Polycystic ovary syndrome (PCOS) is a very common condition affecting 8% to 13% of women. Being overweight worsens all clinical features of PCOS. These clinical features include reproductive issues such as reduced frequency of ovulation and irregular menstrual cycles, reduced fertility, polycystic ovaries on ultrasound and high levels of male hormones such as testosterone, which can cause unwanted facial or body hair growth and acne. PCOS is also associated with metabolic features, with risk factors for diabetes and cardiovascular disease including high levels of insulin or insulin resistance and abnormal cholesterol levels. PCOS affects quality of life and can worsen anxiety and depression either due to its symptoms or due to the diagnosis of a chronic disease.

The Cochrane Gynaecology and Fertility Group (CGF)  is concerned with the systematic evaluation of the management and treatment of menstrual disorders and subfertility. The CGF carries out extensive searches for all relevant randomised controlled trials (RCTs) both published and unpublished; scrutinises each trial for its relevance and quality; critically appraises trials; draws conclusions based on pooling data about how their net result should be applied in healthcare; and produces structured reports (systematic reviews) for widespread dissemination to health care providers and planners, and to consumers.

Here is a curated list of some PCOS related Cochrane systematic reviews:

Tuesday, September 3, 2019

#CochraneSantiago - Let's get social!

Thu, 08/29/2019 - 18:32

We are looking for content creators who would like to help share the work of Cochrane and extend our annual scientific conference materials and discussion beyond attendees to their social media followers.

 Cochrane Chile is hosting Cochrane’s Colloquium in Santiago, October 22-25, 2019. Cochrane’s Colloquium is an annual, global health event based on promoting the most prestigious evidence in the world and where hundreds of international researchers, opinion leaders, health experts and patients join together for open, scientific debate promoting the use of evidence in health. Through talks, workshops and other activities and presentations, we will be exploring this year's theme of “Embracing diversity”.

You can find Cochrane  on TwitterFacebookYouTube, and Instagram. We want to open up the discussion and learning that will be had at our event to everyone who wants to be involved, not just attendees and not just our regular followers. By working with others on social media, we hope to  explore some of the key conference themes and highlight the work of Cochrane to new audiences' including patients, health practitioners, policy-makers, guideline developers, health and science journalists and researchers. 

What we are looking for:

  • Availability between October 22-25 Although it fine to post before and after these dates, Cochrane's Colloquium is being held in Santiago between these dates so we would need you to support this imitative during this time.
  • Creators of content in any language but we are particularly interested in working with English and Spanish creators.
  • Any social media platform - we are looking for pod-casters, bloggers, tweeters, Instagramers! Specialize in one or have many!
  • Have an audience interested in health or evidence-based medicine Your audience may be interested in one specific clinical area or health issue or have a more general interest .
  • Your own voice, your own opinions: We would like you to write in your style and share content that suits your audience. You are welcome to share your opinion on Cochrane or the topics being discussed but it's important that it is clear you are giving your own opinion and not 'speaking for Cochrane'. Please see our Spokesperson Policy.
  • Share evidence, not clinical recommendations: Communications about Cochrane evidence should present the evidence accurately and not make clinical recommendations. However, if you would like to comment on the evidence from your personal/professional experience or on Cochrane, for example for blogs or podcasts, please make it explicit that they are your own opinions.  Please see our Spokesperson Policy.
  • People who respond to comments and encourage discussion. Discussion and debate is great! However we don't encourage responding to abusive comments or comments not relevant to matter under discussion. If individuals would like to raise issues with Cochrane outside of the scope of the social media conversation or have questions that would be better answered by Cochrane, please direct individuals to our 'Contact Us' page.
  • A respectful voice and moderator. All posts and responses should be polite and respect of others' views; even if you don't agree.

If you are selected, we will provide you with:

  • Graphics - Social media graphics you may use.
  • Pictures - of the Colloquium after each day.
  • Suggested content - tweets, content, and discussion points that you can adapt for your own accounts.
  • Hashtags - Suggested hashtags to increase traffic to your content. We have specific hashtags for different events at the conference that we will be encouraging people to use.
  • A shout-out - A profile in a news item on Cochrane.org that links out to your social media accounts; great for increasing your audience but also identifying others you may wish to collaborate with.

If you are attending the Colloquium, you'll also get:

  • Social Media VIP ribbon Wear your special ribbon on your name badge so that you are easily identifiable.
  • Social Media VIP Area A special area to meet-up at breaks with working space and a place to charge your devices.
  • Networking with others doing social media A networking event on Tuesday to kick-off the Colloquium and meet future collaborators.
  • Network with Cochrane staff A chance to meet and chat with Cochrane's Knowledge Translation Department who run Cochrane and Cochrane Library social media accounts and a chance meet the new Editor-in-Chief and the Cochrane Governance - ask them questions and network!

How to apply:

Complete and submit this short survey by 5 October,  telling us about yourself, your social media accounts, and why you would like to get involved.

 

 

Monday, September 9, 2019

Cochrane seeks Office Administrator - London

Thu, 08/29/2019 - 11:21

Specifications: Full Time
Salary: £23,000
Location: London
Application Closing Date: 12th September 2019

This role is an exciting opportunity to use your experience in office administration to make a difference in the field of health care research. 

The Office Administrator will provide effective and efficient administrative support to the EA to the CEO, to ensure smooth running of the London office and administrative functions for the Central Executive Team (CET).

We are looking for a self-motivated and highly organised individual who is able to work effectively and collaboratively with a diverse range of contacts across the world.  If you have experience in a similar role within a government, charity, regulatory, or similar environment; excellent administrative skills; strong communication and interpersonal skills and a ‘can-do’ attitude then we would like to hear from you.  In return, we can offer you a stimulating, highly collegiate, work environment with plenty of scope to make your own mark.

The successful candidate will also have:

Essential:

  • Previous experience of providing administrative support to a team
  • Intermediate level IT skills, including Word, Excel and PowerPoint
  • Strong organization and prioritization skills
  • Excellent written and verbal communication skills
  • Excellent interpersonal skills
  • Professional telephone manner
  •  Ability to work methodically and accurately
  •  A flexible approach with the ability to respond quickly to issues as they arise
  • A pro-active approach to problem-solving
  • Awareness of handling confidential and sensitive information

Preferred:

  • Experience of healthcare charity sector
  • Previous experience of providing PA support

Cochrane is a global, independent network of health practitioners, researchers, patient advocates and others, responding to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesizing research findings to produce the best available evidence on what can work, what might harm and where more research is needed. Our work is recognised as the international gold standard for high quality, trusted information.

If you would like to apply for this position, please send a CV along with a supporting statement to recruitment@cochrane.org with Office Administrator in the subject line.  The supporting statement should indicate why you are applying for the post, and how far you meet the requirements for the post outlined in the job description using specific examples.  List your experience, achievements, knowledge, personal qualities, and skills which you feel are relevant to the post.

  • For further information, please download the full job description from here.
  • Deadline for applications: 12th September 2019
  • Interviews will be held 19th September
Thursday, August 29, 2019

Podcast: The Skeptics' Guide to EM talks about Cochrane and the Cochrane Acute and Emergency Care Network

Wed, 08/28/2019 - 20:17

The Skeptics’ Guide to Emergency Medicine (SGEM)  is a podcast with over 40,000 subscribers and is translated into four other languages. It is  open access with the goal of providing the most valid, reliable, and unbiased global source of currently clinically-relevant patient-centered emergency medicine information.

Recently SGEM talked to Dr. Michael Brown the Senior Editor of the Cochrane Acute and Emergency Care Network. The aim of Cochrane Acute and Emergency Care is to support and help coordinate this work across five Review Groups producing systematic reviews under the topic of Acute and Emergancy Care: Cochrane Acute Respiratory Infections, Cochrane Anaesthesia, Cochrane Bone, Joint and Muscle Trauma, Cochrane Emergency and Critical Care, and Cochrane Injuries.  Michael chatted about Cochrane's work, our mission, and the organization of Review Groups into Networks. 

Wednesday, August 28, 2019

Cochrane seeks Human Resources Manager - London based

Wed, 08/28/2019 - 13:34

Specifications: Full Time
Salary: £60,000
Location: London
Application Closing Date: Friday 13th September 2019

Cochrane is for anyone interested in using high-quality information to make health decisions. Whether you are a doctor or nurse, patient or carer, researcher or funder, Cochrane evidence provides a powerful tool to enhance your healthcare knowledge and decision making.

Cochrane’s 11,000 members and over 68,000 supporters come from more than 130 countries, worldwide. Our volunteers and contributors are researchers, health professionals, patients, carers, and people passionate about improving health outcomes for everyone, everywhere. Our global independent network gathers and summarizes the best evidence from research to help you make informed choices about treatment and we have been doing this for 25 years.

We are looking for an exceptional professional to lead our Human Resources function within the People Services Department.  Reporting to the Head of People Services, your role will involve:

  • working with other senior People Services team members to produce and implement a Cochrane People Strategy that complements Cochrane’s organizational Strategy;
  • delivering HR expertise across the full generalist remit including recruitment, reward, organisational development, change management, employee engagement, employee relations and L&D;
  • Provision of first-class HR transactional services which are highly regarded by end users


If you are CIPD level 7 qualified; have led an HR function in a similar-sized organisation with a complex international footprint; are familiar with expert knowledge workers who are a mixture of employees, consultants and secondees, have a ‘can do’ attitude and are in sympathy with our organizational aims
then we would like to hear from you.  In return, we can offer you a stimulating, highly collegiate, work environment with plenty of scope to make your own mark.

 

Wednesday, August 28, 2019 Category: Jobs

Cancer Council NSW seeks Systematic Reviewer - Australia

Tue, 08/27/2019 - 19:07

Closing date: 5 Sept
Type: 12 month contact

Celebrating over 60 years, Cancer Council NSW is an independent, community funded not for profit with a purpose. What's our point of difference?  We look at all aspects of cancer from research right through to support, with an aim to fund research of the highest scientific merit and value to the community that it serves and represents.

Based in our Woolloomooloo office, you will join our highly regarded Cancer Research Division (CRD), which provides expert, impartial evidence that influences the actions of Cancer Council NSW, policy makers, practitioners and the community to reduce the national and international impact of cancer. 

Research Program

You will contribute to an exciting research program, which aims to determine which cancer control interventions and programs can most effectively and cost-effectively reduce the numbers of people dying from cancer.

This involves modelling cancer mortality rates and numbers of cancer deaths in Australia out to 2040 and the impacts of different cancer control strategies on these rates and numbers.

The initial project findings will be used to guide the process of policy prioritisation for Cancer Councils to support the efficient and effective use of cancer control programs in the prevention, early detection and treatment of cancer at a population level.

Specifically?

The key purpose of this 12mth contract (with potential to be extended) will be to undertake systematic and scoping reviews of the medical and scientific literature to produce evidence-based summaries for inputs for models and publications in peer-reviewed journals and/or scientific reports.

Tuesday, August 27, 2019 Category: Jobs

Cochrane seeks Head of Governance & Strategy Unit - Flexible location, London based preference

Tue, 08/27/2019 - 14:00

Specifications: Full Time
Salary: £70,000
Location: Flexible, though with a preference for London - based
Application Closing Date: Tuesday 17th September 2019

Cochrane is the world’s most respected producer of high-quality health evidence to inform decision-making by healthcare practitioners, patients and carers, researchers and policymakers. Our global independent network of over 11,000 members and 68,000 supporters analyze and summarize the best evidence from research and publish it in the Cochrane Library (www.cochranelibrary.com). Cochrane is passionate about improving health outcomes for everyone, everywhere by helping them to make informed choices about healthcare issues and we have been doing this for 25 years.

We are looking for someone with exceptional leadership skills and experience to join our Senior Management Team as Head of Governance & Strategy. This is a newly-created role leading a Unit that reports to the Chief Executive Officer, and we will look to you to:

  • Act as Company Secretary of The Cochrane Collaboration, ensuring that all the right support structures are in place to enable our Governing Board to meet its responsibilities and obligations;
  • Lead and oversee high-quality support to the Board, its Sub-Committees, the Cochrane Council and other governance bodies. This will include managing the meeting schedule and the development of agendas and supporting documentation;
  • Lead and support Cochrane’s review and impact of our current organizational Strategy to 2020 and the development of our new strategy from January 2021; 
  • Coordinate and oversee development and implementation of project management norms and standards, including the Unit’s technical support to Cochrane Central Executive Team and Cochrane Group staff;
  • Ensure Cochrane develops a robust organizational and programme monitoring and evaluation (M&E) approach, framework and metrics to measure the success and impact of its present and future activities and outputs, and ensure these are communicated and implemented across the organization;
  • Coordinate our approach to Risk Management and lead on reporting organizational risks to the leadership team and our Governing Board.

If you have experience in a senior role within a government, charity, regulatory, or similar environment; excellent analytical skills; proven strategic planning, project management and organisational reporting skills and a ‘can-do’ attitude then we would like to hear from you.  In return, we can offer you a stimulating, highly collegiate, work environment with plenty of scope to make your own mark.

Thursday, August 29, 2019 Category: Jobs

Visit the Cochrane Community Exhibition Stand at the Colloquium

Mon, 08/26/2019 - 13:41

The Cochrane Community Exhibition Stand has traditionally been a hub of activity and a gathering point for both members, staff, and for those new to Cochrane. Come chat to us, get your questions answered, and learn more about Cochrane!

Our annual event, the Cochrane Colloquium, brings together members of the community, staff, and newcomers to Cochrane. Amongst the wide range of workshops, activities, social events, and support we are offering, we would like to ensure that consumers, students, early career professionals, and first time Colloquium participants have easily identifiable people to ask questions to and the chance to learn about the wide a range of Cochrane activities. At breaks or at lunch, we invite you to visit the Cochrane Community Exhibition Stand and come chat with us!

At the stand you will see people wearing a purple Cochrane sash so that you know who to approach if you have questions. Those with sashes have attended multiple Cochrane Colloquia and have a good awareness of Cochrane and our work – they are there for you to ask questions, have a chat and to network with. See you at the Community Booth!

Name: Dario Sambunjak
Country: Croatia
Languages: English, Croatia
Role: Learning Content Officer, Cochrane Training
Will be at the Community Booth: Tuesday afternoon break, Thursday morning break, and  Thursday afternoon break
I have had many roles in Cochrane - Cochrane Croatia Branch Director, author of several Cochrane Reviews, Co-Chair of Colloquia Workshop Programme, and others. Currently I'm involved in developing and supporting training activities (mostly online, but also face-to-face) across the Cochrane community.

 Name: John Hilton
Country: United Kingdom
Languages: English
Role: Editor
Social Media: Twitter, Instagram
I work in the Editorial and Methods Department in the Cochrane Central Executive. Ask me about the Cochrane Library!

 

 Name: Miranda Cumpston
Country: Australia
Languages: English
Role: Handbook Editor, Cochrane Public Health Editor
Social media: Twitter
I've been involved with Cochrane since 2003, primarily as a trainer for Cochrane authors and also as an editor. Recently I've been involved in editing the new edition of the Cochrane Handbook - ask me about the Handbook or about authoring a review.

Name: Muriah Umoquit
Country: Canada
Languages: English
Role: Communications and Analytics Officer, Knowledge Translation Department
Social Media: Twitter, Facebook, Instagram, LinkedIn
I oversee the many internal and external communication channels that Cochrane uses – from newsletters to Instagram. Lets chat about how you are sharing health evidence and how to best reach your intended audience.

Name: Robin Featherstone
Country:  Canada
Languages:English
Role: Information Specialist
Social media: Twitter
I’m an Information Specialist for the Editorial & Methods Department in the Central Executive. Ask me about Cochrane Library, CENTRAL, Cochrane Register of Studies, anything about searching methods to support Cochrane reviews, or about the role of Information Specialists in Cochrane.

 

 Name: Sabrina Khamissa
Country:  United Kingdom
Languages: English
Role: Events and brand Support Officer, Knowledge Translation Department
I'm the Events and Brand Support Officer for Cochrane. I help Cochrane Group's host the Colloquia and Governance Meetings. I also provide marketing, communications and brand support to the community. This will be my first Colloqium! I can support attendees with general information about every aspect of the Colloquium and venue. I can also point you in the right direct for which group/person to speak to, if you need to make contact with some, need advice or want to find out more about a particular project.

 

More profiles of Cochrane Community members helping at the Colloquium Exhibition Stand to be added!

Monday, August 26, 2019

#BetterPoster templates for Cochrane Colloquium attendees

Fri, 08/23/2019 - 13:13

Cochrane’s Colloquium is our annual flagship event, which brings together Cochrane contributors and stakeholders from around the world to discuss Cochrane research, systematic review methods, important global health questions, and promoting evidence-informed health care. This year our 26th annual event will be hosted in Santiago, Chile on 22-25 October 2019.

One important and highly anticipated element of our Colloquium is our poster sessions. This is a great opportunity to browse the work of important studies and speak directly to some of the lead authors. Many collaborations, partnerships, and learning have happened from these sessions.

This year in Chile we have up to 300 posters being presented. Rows of posters with vast text is difficult for attendees to navigate efficiently. We are also aware that many of our attendees will not have English as their native language, making the poster session even harder to navigate. 

As in the past Colloquiums, we offer all attendees the Cochrane branded traditional academic conference template. In addition to this, we are also providing branded #betterposter templates. These new templates offer posters with less text and a decluttered design with the main finding in plain English as the highlighted feature.


 
We have teamed up with Mike Morrison from the Michigan State University. Applying his expertise on industrial-organizational psychology, Mike has created Cochrane branded #betterposter design to help facilitate information exchange at this year’s colloquium.

Below is a quick introduction to these new templates - there is also a longer version to watch that explains the background and demonstrates why the traditional format is ineffective! We understand these videos go quickly and that even with subtitles added in, it may be difficult for those that are not Native-English speakers to follow. Therefore we will be hosting an free webinar in the next month to go over the design and how to edit the templates to create your own poster.


 
We welcome poster presenters to try out this new format – we will be inviting both the presenters and viewers to participate in a larger evaluation study of these templates after the Colloquium.

 

Wednesday, August 28, 2019

The University of Sydney seeks Senior Evidence Analyst - Sydney, Australia

Thu, 08/22/2019 - 14:46

Closing date: 11:30pm, Thursday 29 August 2019
Type: Fixed Term for 12 months with possible annual extension

The Senior Evidence Analyst provides deep technical knowledge and collaborates with academics and research professionals to support the research requirements for the work area. This includes actively leading and contributing to project activities, designing review protocols, undertaking critical aspects of research work including analysis and key findings. Collates research data, draws insights and analyses, reports information from the research undertaken and work with internal and external stakeholders.

The Senior Evidence Analyst will work with the manager and other staff within the SRHTA team to develop systematic reviews and Health Technology Assessments (HTAs) and conduct evidence reviews for HTAs including: development of search strategies, conducting literature searches, review and selection of citations, extraction of data, quality assessment and critical appraisal and writing of reports. Together with conducting work for NHMRC Health Evidence Advice and Methods Panel; conducting evidence reviews and developing protocols the successful incumbent will have strong interpersonal and communication skills to develop and maintain effective relationships with multiple project clients and key clients.

Thursday, August 22, 2019 Category: Jobs

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